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References & Studies

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  1. Shubrook, N. (2023, August 22). Top 5 health benefits of mushrooms. BBC Good Food. Retrieved from:
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  1. Fatima, S., Rasool, A., Sajjad, N., Bhat, E, A., Hanafiah, M, M., Mahboob, M. (2019). Analysis and Evaluation of Penicillin Production by Using Soil Fungi. Biocatalysis and Agricultural Biotechnology, 21.
    https://www.sciencedirect.com/science/article/abs/pii/S1878818119310680
  1. McHale, E. (2020, June 30). Secret Fungi in Everyday Life. Royal Botanic Kew Gardens. Retrieved from:
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  1. Global Mushroom Coffee Market Forecast to 2030: Rising Awareness of the Medicinal Benefits of Mushrooms Drives Growth. (2023, June 20). Yahoo Finance. Retrieved from:
    https://finance.yahoo.com/news/global-mushroom-coffee-market-forecast-134300104.html
  1. Guide to Lion’s Mane Mushroom. (2023, August 17). Holland and Barrett. Retrieved from:
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  1. Perez, A. (2023, June 29). Nine Health Benefits of Lion’s Mane Mushroom: Plus Side Effects. Retrieved from:
    https://www.healthline.com/nutrition/lions-mane-mushroom#depression-and-anxiety
  1. Docherty, S., Doughty, F. L., & Smith, E. F. (2023). The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients, 15(22), 4842.
    https://doi.org/10.3390/nu15224842
  1. Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2011). Effects of Hericium Erinaceus on Amyloid β (25-35) Peptide-induced Learning and Memory Deficits in Mice. Biomedical Research (Tokyo, Japan), 32(1), 67–72.
    https://doi.org/10.2220/biomedres.32.67
  1. Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., Botta, L., Girometta, C., Guglielminetti, M. L., Savino, E., & Rossi, P. (2017). Dietary Supplementation of Hericium Erinaceus: Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evidence-based Complementary and Alternative Medicine: eCAM, 2017, 3864340.
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  1. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2008). Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial. Phytotherapy Research, 23(3), 367-372.
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  1. Mental Health Facts and Statistics. (2020). Retrieved from:
    https://www.mind.org.uk/information-support/types-of-mental-health-problems/statistics-and-facts-about-mental-health/how-common-are-mental-health-problems/#HowCommonAreMentalHealthProblems
  1. Chiu, C. H., Chyau, C. C., Chen, C. C., Lee, L. Y., Chen, W. P., Liu, J. L., Lin, W. H., & Mong, M. C. (2018). Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. International journal of Molecular Sciences, 19(2), 341.
    https://doi.org/10.3390/ijms19020341
  1. Lovering, N. (2024, January 5). Health Benefits of Lion’s Mane. Retrieved from:
    https://www.forbes.com/health/supplements/health-benefits-of-lions-mane/
  1. Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015). Effects of Amycenone on Serum Levels of Tumor Necrosis Factor-α, Interleukin-10, and Depression-like Behavior in Mice After Lipopolysaccharide Administration. Pharmacology, Biochemistry, and Behaviour, 136, 7–12.
    https://doi.org/10.1016/j.pbb.2015.06.012
  1. Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010). Reduction of Depression and Anxiety by Four Weeks Hericium Erinaceus Intake. Biomedical Research, 31(4), 231-237.
    https://doi.org/10.2220/biomedres.31.231
  1. Li, I. C., Chang, H. H., Lin, C. H., Chen, W. P., Lu, T. H., Lee, L. Y., Chen, Y. W., Chen, Y. P., Chen, C. C., & Lin, D. P. (2020). Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium Erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Frontiers in Aging Neuroscience, 12, 155.
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  1. Li, I. C., Lee, L. Y., Tzeng, T. T., Chen, W. P., Chen, Y. P., Shiao, Y. J., & Chen, C. C. (2018). Neurohealth Properties of Hericium Erinaceus Mycelia Enriched with Erinacines. Behavioural Neurology, 2018, 5802634.
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  1. Leonard, J. (2018, October 18). What Are the Benefits of Lion’s Mane Mushroom? Retrieved from:
    https://www.medicalnewstoday.com/articles/323400
  1. Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin Derivatives Activates a Pan-neurotrophic Pathway in Central Hippocampal Neurons Converging to ERK1/2 Signaling Enhancing Spatial Memory. Journal of Neurochemistry, 165, 791–808.
    https://doi.org/10.1111/jnc.15767
  1. Buntajova, D. (2023, February 13). The Mushroom That Could Protect You from Alzheimer’s Disease – ‘Significant Impact’. The Express. Retrieved from:
    https://www.express.co.uk/life-style/health/1734093/dementia-alzheimers-disease-diet-lions-mane-mushroom-lower-risk/amp
  1. Lai, P. L., Naidu, M., Sabaratnam, V., Wong, K. H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. (2013). Neurotrophic Properties of The Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.
    https://doi.org/10.1615/intjmedmushr.v15.i6.30
  1. Kolotushkina, E. V., Moldavan, M. G., Voronin, K. Y., & Skibo, G. G. (2003). The Influence of Hericium Erinaceus Extract on Myelination Process in Vitro. Fiziolohichnyi Zhurnal (Kiev, Ukraine), 49(1), 38–45.
    https://europepmc.org/article/med/12675022
  1. Tsai-Teng, T., Chin-Chu, C., Li-Ya, L., Wan-Ping, C., Chung-Kuang, L., Chien-Chang, S., Chi-Ying, H. F., Chien-Chih, C., & Shiao, Y. J. (2016). Erinacine A-enriched Hericium Erinaceus Mycelium Ameliorates Alzheimer’s Disease-related Pathologies in APPswe/PS1dE9 Transgenic Mice. Journal of Biomedical Science, 23(1), 49.
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  1. Abdullah, N., Ismail, S, M., Aminudin, N., Shuib, A, S., Lau, B, F. (2011). Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine, Vol 2012.
    https://doi.org/10.1155/2012/464238
  1. Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017). Immunomodulatory Activities of a Fungal Protein Extracted from Hericium Erinaceus Through Regulating the Gut Microbiota. Frontiers in Immunology, 8, 666.
    https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00666/full
  1. Trovato, A., Siracusa, R., Di Paola, R., Scuto, M., Ontario, M. L., Bua, O., Di Mauro, P., Toscano, M. A., Petralia, C. C. T., Maiolino, L., Serra, A., Cuzzocrea, S., & Calabrese, V. (2016). Redox Modulation of Cellular Stress Response and Lipoxin A4 Expression by Hericium Erinaceus in Rat Brain: Relevance to Alzheimer’s Disease Pathogenesis. Immunity & Ageing: I & A, 13, 23.
    https://doi.org/10.1186/s12979-016-0078-8
  1. Liang, B., Guo, Z., Xie, F., & Zhao, A. (2013). Antihyperglycemic and Antihyperlipidemic Activities of Aqueous Extract of Hericium Erinaceus in Experimental Diabetic Rats. BMC Complementary and Alternative Medicine, 13, 253.
    https://doi.org/10.1186/1472-6882-13-253
  1. Lion’s Mane Mushroom. (2016, September 8). Alzheimer’s Drug Discovery Foundation. Retrieved from:
    https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
  1. Chen, C. C., Tzeng, T. T., Chen, C. C., Ni, C. L., Lee, L. Y., Chen, W. P., Shiao, Y. J., & Shen, C. C. (2016). Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium Erinaceus. Journal of Natural Products, 79(2), 438–441.
    https://doi.org/10.1021/acs.jnatprod.5b00474
  1. Choi, W. S., Kim, Y. S., Park, B. S., Kim, J. E., & Lee, S. E. (2013). Hypolipidaemic Effect of Hericium Erinaceum Grown in Artemisia Capillaris on Obese Rats. Mycobiology, 41(2), 94–99.
    https://doi.org/10.5941/MYCO.2013.41.2.94
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